This study analyzed patient data from TIAregistry.org to estimate the prevalence of atherosclerosis and associated risk factors in patients who had a transient ischemic attack (TIA) or minor ischemic stroke. The ASCOD grading system was applied to categorize the degree of atherosclerosis and estimate the 5-year risk of major vascular events. The study found that patients with atherosclerosis had a much higher risk of major vascular events within 5 years than those without atherosclerosis. Preventive strategies should focus on individuals with atherosclerosis rather than grouping together all people who have had a TIA or minor ischemic stroke. The study was funded by several organizations, including AstraZeneca and Sanofi.

This study aimed to investigate the feasibility of using endoscopic screening and surveillance as an alternative to prophylactic total gastrectomy in individuals with CDH1 variants, who are at high risk of developing hereditary diffuse gastric cancer. The study involved 270 asymptomatic patients with CDH1 variants who underwent endoscopic screening and surveillance, with a median follow-up of 31.1 months (about 2 and a half years). The findings indicated that endoscopic surveillance was an acceptable alternative to surgery in individuals with CDH1 variants who declined total gastrectomy, with a low rate of incident tumors. This suggests that surveillance could be a viable alternative to surgery for these individuals. The study was funded by the Intramural Research Program at the National Institutes of Health.