Exploring Sleeve Gastrectomy as Alternative to Total Gastrectomy in HDGC: A Prospective Cohort Study

This study aimed to investigate the feasibility of using endoscopic screening and surveillance as an alternative to prophylactic total gastrectomy in individuals with CDH1 variants, who are at high risk of developing hereditary diffuse gastric cancer. The study involved 270 asymptomatic patients with CDH1 variants who underwent endoscopic screening and surveillance, with a median follow-up of 31.1 months (about 2 and a half years). The findings indicated that endoscopic surveillance was an acceptable alternative to surgery in individuals with CDH1 variants who declined total gastrectomy, with a low rate of incident tumors. This suggests that surveillance could be a viable alternative to surgery for these individuals. The study was funded by the Intramural Research Program at the National Institutes of Health.